If NMN can improve the symptoms of patients with Alzheimer's disease (AD) – it will be an important option in treating this disease in the future!
Alzheimer's disease is found in 10-15 percent of people over 65 years old and 20-30 percent of people over 80 years old < In 2018, it was estimated that 5.7 million Americans had Alzheimer's disease. This disease will greatly affect the daily life. It also makes the part of the brain that controls thought. Impaired memory and language.
At present, although still unable to find the true cause of this disease. But it is believed that genetics, lifestyle and environment It is a factor that stimulates Alzheimer's disease. There is a disruption in the functioning of brain cells. And damaged brain cells will lose the coherence of the neural network in the brain.
In the brain, abnormal proteins interfere with brain function, such as the accumulation of ß-amyloid (a toxin) and entangled neurofibrillary tangle proteins.
A team of scientists from Tongji University in Shanghai and Nanjing Medical University have found that NMN can improve symptoms of Alzheimer's disease in mice.
From the experiment it was found that Mice with Alzheimer's disease and receiving NMN had marked improvements in spatial learning > which is cognitive function itself (the process that the brain uses to receive information and make decisions)
Also, mice with Alzheimer's disease and not receiving NMN had reduced spatial learning, while mice with Alzheimer's disease and receiving NMN had better cognitive function. almost the same as that of normal mice.
WT, Vehicle : normal rat
WT, NMN : NMN-treated normal mice
Tg, Vehicle : mice with Alzheimer's disease and not receiving NMN
Tg, NMN : mice with Alzheimer's disease and receiving NMN
From the graph, it can be seen that rightmost bar graph shows that Mice with Alzheimer's receiving NMN had cognitive function similar to that of normal mice.
NMN therapy reduces the levels of ß-amyloid, a toxic protein that forms plaques, in the brains of patients with Alzheimer's disease. and when viewed under a microscope Plaques were found to be reduced in mice with Alzheimer's receiving NMN.
NMN reduces plaque formation in the brains of mice with Alzheimer's disease. From the figure it can be seen that The left-hand brown plaques were formed in the Alzheimer's-afflicted rats' brains; the right-hand ones showed a greater decrease in brown plaques in the Alzheimer's rats. Mercedes and get NMN
NMN treatment reduces nerve inflammation in mice with Alzheimer's disease. The amount of plaque is correlated with nerve inflammation.
This research indicates that NMN may be a novel approach to Alzheimer's disease in the future.