Triple negative breast cancer (TNBC) is the most common type of breast cancer in recent years. It is more severe than normal breast cancer, found about 10-20% of all breast cancers. and often found in young people (usually under 50) and still menstruating The disease is often found in more advanced stages than the common type and is resistant to treatment.
Dr. Luo and his research team. Xinhua University, China, a study in mice found that NMN inhibited the growth and spread of TNBC breast cancer and increased survival.
The research team injected TNBC cancer cells into immunocompromised mice and measured their cancer size, then administered 500 mg/kg/day of NMN daily after 48 days of tumor cell injection. It was found that NMN-treated mice had a 10% reduction in cancer size compared to mice that were not given NMN. also reduced lung metastases by about half.
According to this study, NMN clearly reduced the growth of TNBC cancer. and also reduce the spread to other organs clearly
From the figure - NMN will reduce the size of the cancer by more than 10% and reduce the spread to the lungs by 50%
Left graph Immunocompromised mice. After injecting human breast cancer cells (TNBC), NMN-treated mice (red curve) showed smaller tumor size than NMN-treated mice (blue curve).
Right graph NMN-treated mice (red dots) had 50% fewer lung metastasis of TNBC cells than mice without NMN (blue dots)
Dr. Luo et al. also found that NMN also had an effect on life expectancy, with NMN extending life expectancy by about 15% after injecting TNBC cells, suggesting that NMN increased life expectancy after symptoms. of TNBC
From the graph, the mean life expectancy of mice receiving NMN (red graph) was about 30 weeks and mice not receiving NMN (blue graph) had an average life expectancy of 26 weeks - about 15% improvement.
NMN, when entering the body, will stimulate the protein sirtuin-1 (Sirtuin-1), which will repair DNA and reduce the amount of ROS (Reactive Oxygen Species) in the cell. That is the anti-cancer properties of NMN as a result. is derived from Sirtuin-1 activation, and without Sirtuin-1, NMN is unable to inhibit TNBC cancer cell proliferation.
Conclusion: NMN intake can inhibit the growth and spread of TNBC breast cancer
The cancer-inhibiting properties of NMN are dose-dependent
Interestingly, Dr. Luo and team found that taking NMN, although it reduced cancer growth, But it did not completely inhibit the proliferation of cancer cells. Another study with 250 mg/kg/day of NMN found no inhibition of cancer growth. That means
NMN intake in high doseswill have a full inhibition effect on cancer cells
The use of chemotherapy to treat TNBC cancer is now being accepted. But because of TNBC treatment resistance, it is possible that In the future, NMN may be used in the treatment of TNBC cancer, pending further clinical research.